Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678460
3.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268136
4.
A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors.
RNA
; 17(4): 603-12, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321186
5.
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.
Mol Pain
; 7: 39, 2011 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21599960
6.
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
J Med Chem
; 63(10): 5585-5623, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324999
7.
Inclusion--in whose best interest? How pediatricians can effectively advocate for children with neurodevelopmental disabilities.
Dev Med Child Neurol
; 56(3): 206-9, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23889529
8.
Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.
Front Biosci
; 12: 3781-94, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17485339
9.
Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.
Metabolism
; 56(3): 380-7, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17292727
10.
Outcomes of the Veterans Affairs Low Vision Intervention Trial II (LOVIT II): A Randomized Clinical Trial.
JAMA Ophthalmol
; 135(2): 96-104, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27978569
11.
Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075.
Mol Cancer Res
; 15(1): 35-44, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27707886
12.
Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors.
Mol Cancer Ther
; 16(8): 1511-1520, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28468776
13.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416490
14.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368119
15.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
16.
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
J Med Chem
; 48(16): 5295-304, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078847
17.
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
Mol Endocrinol
; 17(6): 1131-43, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12649327
18.
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
J Med Chem
; 47(17): 4213-30, 2004 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15293993
19.
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
J Med Chem
; 46(6): 1016-30, 2003 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12620078
20.
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic Clin Pharmacol Toxicol
; 95(3): 144-52, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15447739